protein

TOPCOMP

Interface to the TOPCOMP database. Returns a zip file with data on a given protein in the TOPCOMP-format.

Given the amino acid sequence of a putative alpha-helical membrane protein, TOPCONS predicts the topology of the protein, i.e. a specification of the membrane spanning segments and their IN/OUT orientation relative to the membrane. The prediction is a consensus from five different topology prediction algorithms: SCAMPI (single sequence mode), SCAMPI (multiple sequence mode), PRODIV-TMHMM, PRO-TMHMM and OCTOPUS.

This service allows the CATH database to be searched by protein structure.

NB This service is not currently active. It is still in development -- check back here for updates. The WSDL posted may change between now and the first release.

This service allows the CATH and Gene3D HMM libraries to be searched with a given amino acid sequence (or any one of various database identifiers representing a sequence).

NB This service is not currently active. It is still in development -- check back here for updates. The WSDL posted may change between now and the first release.

FuncNet is a distributed protein function comparison pipeline, funded by the European Union's EMBRACE Network of Excellence.

The objective of FuncNet is to provide an open platform for the computational prediction and analysis of protein function.

It is designed to answer questions like:

Given one set of proteins which are known to share a particular biological function...

... which of these other proteins also share that function?

This service allows you to submit requests to the FuncNet pipeline, which are then forwarded on to the component prediction services.

For a guide to using FuncNet, including source code and example SOAP messages, please see http://funcnet.eu/getting-started/

The individual prediction services within FuncNet are also available for direct querying; for details, please see http://funcnet.eu/wsdls/